El Paso's centralized location offers rail routes to Chicago, Los Angeles, San Francisco, New Orleans, Dallas, Austin, Midland, Kansas City, Denver, Salt Lake City, and Albuquerque. Rail service from El Paso is provided by both the Burlington Northern and Santa Fe Railway Company (BNSF) and Union Pacific.

"El Paso represents the natural border crossing for all traffic moving to and from the Western United States, and is an efficient Mexican gateway benefiting customers." - Rogelio Vélez, Ferrocarril Mexicano Vice President, Marketing